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KMID : 0352720180420030361
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Journal of Ginseng Research
2018 Volume.42 No. 3 p.361 ~ p.369
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Micro-/nano-sized delivery systems of ginsenosides for improved systemic bioavailability
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Kim Hyeong-Min
Lee Jong-Hyuk
Kim Jee-Eun
Kim Young-Su
Ryu Choong-Ho
Lee Hong-Joo
Kim Hye-Min
Jeon Hyo-Jin
Won Hyo-Joong
Lee Ji-Yun
Lee Jae-Hwi
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Abstract
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Ginsenosides, dammarane-type triterpene saponins obtained from ginseng, have been used as a natural medicine for many years in the Orient due to their various pharmacological activities. However, the therapeutic potential of ginsenosides has been largely limited by the low bioavailability of the natural products caused mainly by low aqueous solubility, poor biomembrane permeability, instability in the gastrointestinal tract, and extensive metabolism in the body. To enhance the bioavailability of ginsenosides, diverse micro-/nano-sized delivery systems such as emulsions, polymeric particles, and vesicular systems have been investigated. The delivery systems improved the bioavailability of ginsenosides by enhancing solubility, permeability, and stability of the natural products. This mini-review aims to provide comprehensive information on the micro-/nano-sized delivery systems for increasing the bioavailability of ginsenosides, which may be helpful for designing better delivery systems to maximize the versatile therapeutic potential of ginsenosides.
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KEYWORD
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bioavailability, delivery system, ginsenosides, permeability, solubility
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